Familial amyloidotic polyneuropathy (FAP) is an inherited systemic amyloidosis, characterized by the extracellular deposition of fibrillar amyloid protein, i.e. a variant type of prealbumin, and by prominent peripheral nerve involvement. We recently established the basis of FAP, using a cloned human prealbumin cDNA, restriction endonuclease(s) and Southern blot procedures. This approach clearly revealed a direct link between mutation in the prealbumin gene and FAP; individuals with FAP are heterozygous for the prealbumin gene, carrying one normal and one mutant gene. Molecular (...) analysis of the prealbumin gene yielded pertinent data on the genetic basis for FAP. (shrink)

A sense of agency (SoA) is the experience of subjective awareness regarding the control of one’s actions. Humans have a natural tendency to generate prediction models of the environment and adapt their models according to changes in the environment. The SoA is associated with the degree of the adaptation of the prediction models, e.g., insufficient adaptation causes low predictability and lowers the SoA over the environment. Thus, identifying the mechanisms behind the adaptation process of a prediction model related to the (...) SoA is essential for understanding the generative process of the SoA. In the first half of the current study, we constructed a mathematical model in which the SoA represents a likelihood value for a given observation (sensory feedback) in a prediction model of the environment and in which the prediction model is updated according to the likelihood value. From our mathematical model, we theoretically derived a testable hypothesis that the prediction model is updated according to a Bayesian rule or a stochastic gradient. In the second half of our study, we focused on the experimental examination of this hypothesis. In our experiment, human subjects were repeatedly asked to observe a moving square on a computer screen and press a button after a beep sound. The button press resulted in an abrupt jump of the moving square on the screen. Experiencing the various stochastic time intervals between the action execution button-press) and the consequent event square jumping caused gradual changes in the subjects' degree of their SoA. By comparing the above theoretical hypothesis with the experimental results, we concluded that the update (adaptation) rule of the prediction model based on the SoA is better described by a Bayesian update than by a stochastic gradient descent. (shrink)

Este relato de experiência discute um eixo de um projeto de ensino, pesquisa e extensão multi e interdisciplinar sobre educação e humanização da morte. Trata-se de ações da Psicologia destinadas à saúde mental dos trabalhadores do serviço funerário da cidade de São Paulo. A intervenção dividiu-se em duas etapas: visitas aos cemitérios, para aproximação daqueles pesquisadores à realidade e às demandas desses servidores; e oficinas com técnicas de dinâmica de grupo. Estas aconteceram por cinco meses, contaram com 130 participantes — (...) motoristas, sepultadores, “veloristas”, supervisores e gestores de recursos humanos — e tiveram como facilitadoras as integrantes da graduação e da pós-graduação em Psicologia. A análise das oficinas evidenciou, da parte dos servidores, sensibilização para suas necessidades em favor da saúde mental, percepção do valor de cuidado e humanização em suas relações profissionais e pessoais. Ademais, ações como essa realçaram a relevância de frequente acolhimento psicólogico a trabalhadores de serviços funerários. (shrink)

Background Informed consent is a requirement for all research. It is not, however, clear how much information is sufficient to make an informed decision about participation in research. Information on an online questionnaire about childhood development was provided through an unfolding electronic participant sheet in three levels of information. Methods 552 participants, who completed the web-based survey, accessed and spent time reading the participant information sheet (PIS) between July 2008 and November 2009. The information behaviour of the participants was investigated. (...) The first level contained less information than might be found on a standard PIS, the second level corresponded to a standard PIS, and the third contained more information than on a standard PIS. The actual time spent on reading the information provided in three incremental levels and the participants' evaluation of the information were calculated. Results 77% of the participants chose to access the first level of information, whereas 12% accessed the first two levels, 6% accessed all three levels of information and 23% participated without accessing information. The most accessed levels of information were those that corresponded to the average reading times. Conclusion The brief information provided in the first level was sufficient for participants to make informed decisions, while a sizeable minority of the participants chose not to access any information at all. This study adds to the debate about how much information is required to make a decision about participation in research and the results may help inform the future development of information sheets by providing data on participants' actual needs when deciding about questionnaire surveys. (shrink)

How to introduce 'politics' as a specific concept within a deconstructive style of thinking? In order to answer this question, this contribution compares Derrida with Laclau. According to the former the starting-point of a deconstructive style of thinking is différance. It links together the economic detour of homecoming and the relation to otherness. Laclau's analysis of politics as hegemonization within a situation of undecidability presupposes this notion of différance and can therefore be useful in introducing politics within a deconstructive style (...) of thinking. But there still is a major difference between Derrida and Laclau's decisionism: if différance as the relation without relation of economy and otherness cannot avoid decisions based on power in order to stabilize the social, these decisions are always marked by passivity and therefore deconstructible in the name of 'justice' that exceeds politics even if it takes place nowhere but within politics. Key Words: decisionism • . Derrida • . hegemony • . Laclau • . law. (shrink)

ヒマラヤ山脈から赤道近辺に及ぶ広大なインド亜大陸。過酷な気象条件のもとに暮らす人々が現代まで連綿と受け継いできた“インド的”な思考の根底にあるものを、ヒンドゥー教ほか正統派とされている思想に焦点を当て ひもとく。.

Located at the junction of trade routes between Prichernomorje and the Mediterranean, Crimea has always been in the sphere of ethnomigratory processes. Therefore, it is natural that the elements of the Scythian, Greek, Gothic, Hun, Khazar, Kypchak and Turkomyslian cultures influenced the formation of the spiritual and material culture of the Crimean Tatar people. The variety of ethnoses that have changed continuously over the centuries has been reflected in the dialectal structure of the Crimean Tatar language that exists up to (...) the present time. (shrink)